Posted by reCellorCircadian AM+PM
on November 03, 2025
Reading time: 8~9 minutes
Last Updated November 12, 2025
NAD⁺ oscillates over 24 hours and feeds back into core clock proteins. Timing isn’t a vibe—it’s biochemistry.†
Morning and night are different physiological contexts. AM emphasizes energy and focus; PM emphasizes calm, sleep quality, and overnight repair.†
“Time‑aligned” doesn’t mean complicated. Small choices—meal timing, light, caffeine, dose timing—stack into noticeable differences over 1–2 weeks.†
Clock → NAD⁺: The CLOCK:BMAL1 complex drives NAMPT, the gatekeeper of the NAD⁺ salvage pathway. Result: NAD⁺ availability rises and falls rhythmically across the day.
NAD⁺ → Clock: SIRT1 uses NAD⁺ to de‑acetylate clock components (e.g., PER proteins), tuning the “timekeeping” loop. When NAD⁺ changes, the clock hears it.
Outcome you feel: You may notice steadier daytime energy and more natural evening calm as your body’s rhythms align.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
